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CHOLINERGICS

AntiCholinesterases Inhibit the Enzyme AcetylCholinesterases and have Same Clinical Effects as Cholinergicagonists.

The Active site for AcetylCholinesterases is similar to the Binding Site for the Cholinergic Receptor, but also Includes the Amino Acids

Histidine and Serine. NeuroMuscular Blocking Activity for Tubocurarine is Associated with a Pharmacophore, where the Distance between

the Two Charged Nitrogen Atoms is 1.15 nm. Octamethonium is an Analogue of Decamethonium, and contains an Eight - Carbon Bridge

between the charged Nitrogen Atoms. The most stable conformation for this Structure is the Fully Extended One.

Where the N - N Distance is 1.157 nm.Where as Octamethonium is likely to be more active than Decamethonium.